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Xalatan eye drops – consumer medicines information leaflets of prescription and over-the-counter medicines.

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Avoid using too much of this medicinewhich can actually make it less effective in lowering the pressure inside the eye.

Tell your doctor rightaway if you have an eye injury or eye infectionor if you plan to have eye surgery.

There is practically no metabolism of the acid of latanoprost in the eyeThe main metabolism occurs in the liverThe half life in plasma is 17 minutes in manThe main metabolitesthe 1,2-dinor and 1,2,3,4-tetranor metabolitesexert no or only weak biological activity in animal studies and are excreted primarily in the urine.

The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytesAfter discontinuation of latanoprostpigmentation of the iris is likely to be permanentwhile pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patientsPatients who receive treatment should be informed of the possibility of increased pigmentationBeyond 5 years the effects of increased pigmentation are not knownsee Clinical Studies

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