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Digoxin increases the strength and efficiency of heart contractionsand is useful in the treatment of heart failure and control the rate and rhythm of the heartIt is extracted from the leaves of a plant called digitalis lanataDigoxin increases the force of contraction of the muscle of the heart by inhibiting the activity of an enzymeATPasethat controls movement of calciumsodiumand potassium into heart muscleCalcium controls the force of contractionInhibiting ATPase increases calcium inheart muscle and therefore increases the force of heart contractionsDigoxin also slows electrical conduction between the atria and the ventricles of the heart and is useful in treating abnormally rapid atrial rhythms such as atrial fibrillationatrial flutterand atrial tachycardiaAbnormally rapid atrial rhythms can be caused by heart attacksexcessive thyroid hormonesalcoholisminfectionsand many other conditionsDuring rapid atrial rhythmselectrical signals from the atria cause rapid contractions of the ventriclesRapid ventricular contractions are inefficient in pumping blood containing oxygen and nutrients to the bodycausing symptoms of weaknessshortness of breathdizzinessand even chest painDigoxin alleviates these symptoms by blocking the electrical conduction between the atria and ventriclesthus slowing ventricular contractionsThe FDA approved digoxin in 1975.

Drugs such as gentamicintetracyclineranolazineRanexaverapamilCalanVerelanVerelan PMIsoptinIsoptin SRCovera-HSquinidineQuinagluteQuinideamiodaroneCordaroneindomethacinIndocinIndocin-SRalprazolamXanaxXanax XRNiravamspironolactoneAldactoneand itraconazoleSporanoxcan increase digoxin levels and the risk of toxicityThe co-administration of digoxin and beta-blockersfor example propranololInderalInderal LAor calcium channel blockers or CCBsfor exampleverapamilwhich also reduce heart ratecan cause serious heart rate slowingDiuretic-inducedfor exampleby furosemideLasixreduction in blood potassium or magnesium levels may predispose patients to digoxin-induced abnormal heart rhythmsSaquinavirInviraseand ritonavirNorvirincrease the amount of digoxin in the body and may cause digoxin toxicityMirabegronMybetriqincreases digoxin blood levelsThe lowest dose of digoxin should be used if by people who are also using mirabegronOmeprazolePrilosecand other drugs that reduce stomach acidity may increase blood levels of digoxin.

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